Paraoxonase gene polymorphisms and oxidative stress

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منابع مشابه

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.

CONTEXT Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. The relationship between PON1 genotypes and functional activity with systemic measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been systematically investigated. OBJECTIVE To investigate the relationship of genetic and biochemical determinants of PON1 activity with ...

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XPD and hOGG1 gene polymorphisms in reperfusion oxidative stress.

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD ...

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Paraoxonase: The boon against oxidative stress and lipid peroxidation

Coronary Artery disease (CAD) is estimated to be the number one cause of morbidity and mortality in the developing world. It is a multifactorial disease and diet plays an important role the development of CAD, and the risk further increases in the presence of dyslipidaemia. The lipoprotein profile is found to be deranged mostly in CAD. Low density lipoprotein cholesterol (LDL) is considered as ...

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Serum paraoxonase enzyme activity and oxidative stress in obese subjects.

INTRODUCTION Obesity is an important risk factor for atherosclerotic cardiovascular disease. Paraoxonase-1 (PON1) may play a significant role in the prevention of obesity-related accelerated atherosclerosis by hydrolyzing lipid peroxides in oxidized low-density lipoproteins. OBJECTIVES The aim of this study was to evaluate PON1 and arylesterase enzyme activities and lipid hydroperoxide (LOOH)...

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Alzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms

BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...

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ژورنال

عنوان ژورنال: American Journal of Hypertension

سال: 2004

ISSN: 0895-7061

DOI: 10.1016/j.amjhyper.2004.03.204